Os04g0479000
The rice Os04g0479000 was reported as CRC1 in 2013 [1] by researchers from China.
Contents
Annotated Information
Gene Symbol
- Os04g0479000 <=> CRC1,OsCRC1
Function
- CRC1 colocalizes with ZEP1, the rice SC transverse filament protein, to the central region of SCs in a mutually dependent fashion. Consistent with this colocalization, CRC1 interacts with ZEP1 in yeast two-hybrid assays.
- CRC1 is essential for meiotic DSB formation, CRC1 Is a Prerequisite for Abnormal Chromosome Entanglement and Fragmentation in rec8 Meiocytes.
- CRC1 interacts with HOMOLOGOUS PAIRING ABERRATION IN RICE MEIOSIS1 (PAIR1) in vitro, suggesting that these proteins act as a complex to promote DSB formation.
- PAIR2, the rice ortholog of budding yeast homolog pairing1, is required for homologous chromosome pairing. The searchers found that CRC1 is also essential for the recruitment of PAIR2 onto meiotic chromosomes.
Figure 4. (A) Comparison of meiotic chromosome behavior in rec8 and rec8 crc1. Bars = 5 mm.(B).Immunostaining for gH2AX (red) in the wild type and crc1-1 at zygotene. Chromosomes were stained with 4,6-diamidino-2-phenylindole (DAPI;blue). REC8 signals (green) were used to indicate the meiocytes. Bars = 5 mm.[1].
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Labs working on this gene
- State Key Laboratory of Plant Genomics and Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
- Key Laboratory of Crop Genetics and Physiology of Jiangsu Province/Key Laboratory of Plant Functional Genomics of Ministry of Education, Yangzhou University, Yangzhou 225009, China
References
- ↑ 1.0 1.1 Miao C, Tang D, Zhang H, Wang M, Li Y, Tang S, Yu H, Gu M, Cheng Z. Central region component1, a novel synaptonemal complex component, is essential for meiotic recombination initiation in rice. Plant Cell. 2013 Aug;25(8):2998-3009. doi: 10.1105/tpc.113.113175. Epub 2013 Aug 13. PubMed PMID: 23943860;
