Os02g0818000

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The rice Os02g0818000 was reported as OsCBSX3a in 2009 [1] by researchers from India.

Annotated Information

Gene Symbol

  • Os02g0818000 <=> OsCBSX3a

Function

  • CBS domains are found to be associated with several proteins of unrelated functions, such as inosine-5'-mono- phosphate dehydrogenase (IMPDH), AMP-activated protein kinase (AMPK), chloride channels (CLC) and cys-tathionine-β-synthase (CBS).
  • Mutation in CBS domains abolish or strongly reduce activation by SAM and cause homocystinuria.
  • CBS domain of γ-subunit of AMPK acts as sensor of cellular energy status and mutations cause a glycogen storage disease, which is clinically expressed as a familial hypertrophic cardiomyopathy.

Evolution

  • CBS domain exists not only in archaebacterial proteins, but also in eubacterial and eukaryotic proteins
  • In CBS protein, C-terminal CBS domain exerts an autoin-hibitory effect on the CBS activity, while binding of SAM (S-adenosylmethionine) with CBS domain induces a conformational change which relieves the autoinhibitory effect.

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Labs working on this gene

  • Centre for Computational Biology and Bioinformatics, School of Information Technology, Jawaharlal Nehru University, New Delhi 110067, India
  • Plant Molecular Biology, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India
  • Stress Physiology and Molecular Biology, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India

References

  1. Kushwaha HR, Singh AK, Sopory SK, Singla-Pareek SL, Pareek A. Genome wide expression analysis of CBS domain containing proteins in Arabidopsis thaliana (L.) Heynh and Oryza sativa L. reveals their developmental and stress regulation. BMC Genomics. 2009 Apr 28;10:200. doi: 10.1186/1471-2164-10-200. PubMed PMID: 19400948; PubMed Central PMCID: PMC2694836.

Structured Information