This gene encodes a putative rust resistance kinase Lr10, and its functions are unknown.
This gene is characterized from the cultivar Nipponbare, and is postulated to encode a putative rust resistance kinase Lr10-like protein which belongs to
the protein kinase superfamily. Even though the functions of the gene are unknown, some functions can still be learned by homologous prediction. The
protein harbors Tyrosine potentiality, protein kinases by its PKc-like catalytic domain, and transferase activity. The protein also contains an
ATP-binding site and a substrate binding site.The Lr10-like protein is expressed to resist the infectious agent Magnaporthe grisea, also known as rice
blast fungus. This fungus can cause causes a serious disease affecting rice,such as rice rotten neck, rice seedling blight and blast of rice.
The rice gene corresponding to Lr10 was mapped on rice chromosome 1, where it occurred in many copies. The Lr10-like protein is expressed in the
rice leaf, and the expresssion is regulated by a complex signal pathway net. However, the regulation mechanism of LR-10 expression in rice is still
The Lr-10 belong to a superfamily including over 50 members. The Lr10 gene originates from hexaploid wheat and is located on chromosome 1AS. The
Lr1 and Lr9 resistance gene in wheat is intensively researched, but the evolution is still in blank.
Labs working on this gene
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Gallego F, Feuillet C, Messmer M, et al.Comparative mapping of the two wheat leaf rust resistance loci Lr1 and Lr10 in rice and barley. Genome.1998 Jun;41(3):328-36.[PMID: 9729767] []
Catherine Feuillet, Silvia Travella, Nils Stein,et al.Map-based isolation of the leaf rust disease resistance gene Lr10 from the hexaploid wheat (Triticum aestivum L.) genome. PNAS.2003; 100(25): 15253–15258.PMCID: PMC299976. [doi: 10.1073/pnas.2435133100][]